Definitions:

  p53 targets: the 116 establised p53 targets (PMID:28288132).
  WT-up genes: the 157 genes subjected to upregulation of wild-type p53 according to the TCGA Pan-Cancer Atlas
  MUT-up genes: the 140 genes subjected to upregulation of frequent p53 missense mutants according to the TCGA Pan-Cancer Atlas